Glimepiride 1mg + Metformin 500 mg + Pioglitazone 15 mg (SR)

Glimepiride 1mg + Metformin 500 mg + Pioglitazone 15 mg (SR)
Glimepiride 1mg + Metformin 500 mg + Pioglitazone 15 mg (SR)
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Product Code : 47
Brand Name : Glupride-MP1
Product Description
Glimepiride 1mg + Metformin 500 mg + Pioglitazone 15 mg (SR)

Glimepiride: The primary mechanism of action of glimepiride in lowering blood glucose appears to be dependent on stimulating the release of insulin from functioning pancreatic beta cells. In addition, extra-pancreatic effects may also play a role in the activity of sulphonylureas such as glimepiride. Metformin: Metformin improves glucose tolerance in patients with type-2 diabetes (NIDDM), lowering both basal and postprandial plasma glucose. Metformin decreases hepatic glucose production, decreases intestinal absorption of glucose, and improves insulin sensitivity by increasing peripheral glucose uptake and utilization. Voglibose: Voglibose is an alpha glucosidase inhibitor which reduces intestinal absorption of starch, dextrin, and disaccharides by inhibiting the action of ±-glucosidase in the intestinal brush border. Inhibition of this enzyme catalyzes the decomposition of disaccharides into monosaccharides and slows the digestion and absorption of carbohydrates; the post-prandial rise in plasma glucose is blunted in both normal and diabetic subjects resulting in improvement of post prandial hyperglycemia and various disorders caused by hyperglycemia. ±-Glucosidase inhibitors do not stimulate insulin release and therefore do not result in hypoglycemia

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