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It is an anti-ulcerant and anti-emetic combination that addresses acid-reflux issues, different types of ulcers, nausea and vomiting. Rabeprazole is a proton pump inhibitor, while domperidone is a dopamine antagonist. Studies show that the combination of rabeprazole and domperidone effectively addresses gastroesophageal reflux disorder than rabeprazole alone.
Rabeprazole is a substituted benzimidazole and it works as a proton pump inhibitor (PPI). After the administration, rabeprazole is absorbed by the parietal cells. Rabeprazole is activated in the acidic environment only. The activated rabeprazole binds to the H+/ K+ ATPase system present on the parietal cells and prevents the inward movement of H+ ions into the stomach and inhibits the gastric acid production.
Domperidone is a strong anti-emetic and anti-ulcerant agent that controls nausea and vomiting along with the suppression of acid-reflux. On peripheral levels, it increases the lower esophageal pressure, improves the motility in the upper GI tract or peristalsis. Centrally, domperidone acts as an antagonist of D2 and D3 dopamine receptors in the area postrema of the brain where the chemoreceptor trigger zone for nausea and vomiting is present.